The proliferation of digital health devices and solutions is at hand. Demand exists around every corner with applications ranging from personal wellness to remote patient monitoring. They are being offered by industry stalwarts and upstarts alike. Collaborations amongst tech companies, academics, big data providers, entrepreneurs and traditional healthcare players—all of whom bring something valuable to the table and all of whom want to be involved in delivering solutions that can help predict, prevent or more effectively respond to disease—are catalyzing digital health product and service development. These new relationships are bringing the power of multiple competencies and game-changing perspectives to today’s health care challenges. They have the potential to revolutionize the way we approach health care delivery. The question is: do these players really know what it will take to work together successfully and, if so, will they be able to get digital health solutions over the finish line?